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. 2020 Aug 25;39:168. doi: 10.1186/s13046-020-01673-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Downregulation of CREB5 inhibits the invasion and metastasis of CRC cells in vivo and in vitro. a and b Wound-healing assay and transwell migration assay were performed to evaluate the invasive and migratory abilities of CRC cells with different treatments in vitro. c HUVEC tube formation after stimulation with the indicated conditioned medium. d Representative images of the CAM assay. Histograms show the formation of secondary and tertiary blood vessels after stimulation with the indicated conditional medium. Scale bar: 2 mm. e Orthotopic transplantation with the indicated HCT116 cells in nude mice (n = 9 in each group) was performed, and representative gross images of the livers and intestines are shown. The arrows indicated the tumors. Liver sections were stained with haematoxylin and eosin (H&E). Scale bar: 50 μm. f The Kaplan-Meier method was used to analyse survival curves in the specified treatment groups, and the log-rank test was used to compare differences. ** p < 0.01