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. 2020 Aug 25;39:168. doi: 10.1186/s13046-020-01673-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Overexpression of CREB5 promotes the invasion and metastasis of CRC cells, but inhibition of MET weakens these effects. a and b The invasive and migratory abilities of CRC cells in vitro with different treatments were evaluated by wound-healing assay and transwell migration assay. c HUVEC tube formation after stimulation with the indicated conditional medium. d Representative images of the CAM assay. Histograms show the formation of secondary and tertiary blood vessels after stimulation with the indicated conditional medium. Scale bar: 2 mm. e Orthotopic transplantation with the indicated SW480 cells in nude mice (n = 9 in each group) was conducted, and representative gross images of the livers and intestines are shown. The arrows indicate the tumors. Liver sections were stained by H&E. Scale bar: 50 μm. f The Kaplan-Meier method was used to analyse the survival curves of different treatment groups, and the log-rank test was used to compare differences. ** p < 0.01, *** p < 0.001, **** p < 0.0001