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. 2020 Aug 25;39:168. doi: 10.1186/s13046-020-01673-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — CREB5 positively correlated with MET expression in CRC. a Correlation analysis of CREB5 and MET in TCGA CRC data (r = 0.260, p < 0.001). b and c Correlation analysis of CREB5 and MET at the mRNA (r = 0.693, p = 0.026) and protein levels (r = 0.725, p = 0.018) in 10 fresh CRC tissues. d The expression of CREB5 and MET protein in specimens, including 78 colon cancer tissue specimens and 2 adjacent normal tissue specimens, was detected by IHC. Representative IHC images (left) and correlation analysis (right) of CREB5 and MET expression. Scale bar: 50 μm. High expression of CREB5: n = 73 (high expression of MET: n = 52). Low expression of CREB5: n = 5 (low expression of MET: n = 4) (p < 0.001)