Table 2.

Univariate and multivariate Cox analysis for overall survival (n = 1177)

	Univariate			Multivariate
	HR	95% CI	p - value	HR	95% CI	p - value
Age > 65	1.482	1.266–1.734	< 0.001	1.476	1.245–1.750	< 0.001
Sex (male)	1.178	1.008–1.377	0.039	1.097	0.926–1.299	0.284
ECOG PS ≥ 2	1.648	1.385–1.961	< 0.001	1.495	1.240–1.802	< 0.001
Hb < 10.0 g/dL	1.271	1.086–1.488	0.003	1.030	0.852–1.244	0.763
Calcium ≥10.2 mg/dL	1.372	1.117–1.686	0.003	1.124	0.896–1.409	0.312
Diagnosis at 2009–2014a	0.638	0.386–1.054	0.079
Diagnosis at 2015–2017a	0.641	0.388–1.062	0.084
Log2 EASIX > 1.87	1.878	1.600–2.205	< 0.001	1.444	1.170–1.780	0.001
ISS 2b	1.361	1.527–2.300	< 0.001	1.226	0.966–1.557	0.094
ISS 3b	1.874	1.101–1.682	< 0.001	1.309	1.000–1.714	0.050
High-risk CA	1.838	1.469–2.300	< 0.001	1.565	1.241–1.973	< 0.001

Abbreviations: ECOG PS Eastern Cooperative Oncology Group Performance Status, Hb Hemoglobin, EASIX Endothelial Activation and Stress Index, ISS International Staging System, R-ISS Revised-International Staging, System, CA Chromosomal abnormality

^a Diagnosis at 2003–2008 is the reference

^bISS 1 is the reference