Table 1.

Overview of the classic psychedelic drugs.

Hallucinogen	Chemical class	Potential therapeutic applications	Therapeutic mechanisms
Ayahuasca/DMT	Tryptamine	Anxiety,10 depression,11 substance misuse12	Increased BDNF,11 neurogenesis/plasticity,13 MAO Inhibition11
LSD	Tryptamine	Anxiety,14 depression,15 substance misuse16	Amygdala and DMN alterations,17 mystical experience18
Mescaline	Phenethylamine	No clinical applications studied to-date
Psilocybin	Tryptamine	Anxiety,19 depression,20 OCD,21 substance misuse22	Amygdala and DMN alterations,23 mystical experience,22 neurogenesis/plasticity24

BDNF, brain-derived neurotrophic factor; DMT, N,N-dimethyltryptamine; LSD, lysergic acid diethylamide; MAO, monoamine oxidase inhibitor; OCD, obsessive-compulsive disorder.