Supplementary Table 2.
Cox regression models for OS in patients with ESOS in the IPTW cohort.
| Characteristic | Model 1* (weighted cohort) | Model 2** (weighted cohort) | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Chemotherapy | No | Reference | NA | Reference | NA |
| Yes | 0.737 (0.533–1.021) | 0.066 | 0.735 (0.529–1.019) | 0.065 | |
| Age(year) | <60 | Reference | NA | Reference | NA |
| ≥60 | 2.066 (1.472–2.901) | <0.001 | 2.239 (1.575–3.183) | <0.001 | |
| Gender | Male | Reference | NA | ||
| Female | 0.865 (0.578–1.294) | 0.481 | |||
| Race | White | Reference | NA | Reference | NA |
| Black | 0,817 (0.448–1.491) | 0.509 | 0.897 (0.488–1.648) | 0.727 | |
| Other | 0.679 (0.346–1.331) | 0.259 | 0.649 (0.325–1.297) | 0.221 | |
| Insurance type | Insured | Reference | NA | ||
| Any medicaid | 1.339 (0.639–2.803) | 0.439 | |||
| Unknown | 1.787 (0.869–3.673) | 0.114 | |||
| Marital status | Single | Reference | NA | Reference | NA |
| Widowed/divorced | 1.238 (0.705–2.175) | 0.458 | 1.361 (0.774–2.393) | 0.285 | |
| Married | 1.074 (0.624–1.847) | 0.798 | 1.116 (0.645–1.929) | 0.695 | |
| Unknown | 2.824 (0.992–8.039) | 0.052 | 2.222 (0.801–6.955) | 0.171 | |
| Year of diagnosis | 1976 to 1985 | Reference | NA | ||
| 1986 to 1995 | 1.405 (0.754–2.621) | 0.284 | |||
| 1996 to 2005 | 0.903 (0.511–1.599) | 0.727 | |||
| 2006 to 2016 | 2.078(0.917–4.707) | 0.079 | |||
| Primary site | Extremity | Reference | NA | Reference | NA |
| Trunk | 2.347 (1.605–3.433) | <0.001 | 2.559 (1.709–3.833) | <0.001 | |
| Visceral | 3.071 (1.918–4.919) | <0.001 | 3.384 (2.078–5.509) | <0.001 | |
| Other | 1.097 (0.593–2.029) | 0.769 | 1.184 (0.637–2.202) | 0.593 | |
| Grade | Grade I/II | Reference | NA | Reference | NA |
| Grade III/IV | 1.383 (0.747–2.562) | 0.302 | 1.235 (0.598–2.551) | 0.568 | |
| Unknown | 1.222 (0.643–2.323) | 0.541 | 1.162 (0.579–2.334) | 0.672 | |
| Stage | Localized | Reference | NA | Reference | NA |
| Regional | 1.632 (1.139–2.37) | <0.001 | 1.629 (1.119–2.371) | 0.010 | |
| Distant | 2.204 (1.376–3.532) | <0.001 | 2.311 (1.364–3.916) | 0.002 | |
| Unstaged | 1.114 (0.521–2.377) | 0.781 | 1.093 (0.487–2.455) | 0.829 | |
| Tumor size (mm) | <73 | Reference | NA | Reference | NA |
| ≥73 | 3.969 (2.805–5.616) | <0.001 | 4.095 (2.840–5.904) | <0.001 | |
| Radiation | Yes | Reference | NA | ||
| No | 0.757 (0.509–1.126) | 0.169 | |||
| Surgery | Yes | Reference | NA | Reference | NA |
| No | 2.841 (1.716–4.701) | <0.001 | 3.049 (1.811–5.133) | <0.001 | |
CI – confidence interval; EOSS – extraskeletal osteosarcoma; IPTW – inverse probability of treatment weighting; NA – not applicable; HR – hazard ratio; mm – millimeter; OSM – osteosarcoma.
*
Multivariable Cox regression adjusted for chemotherapy, age, race, marital status, primary site, grade, stage, tumor size and surgery in the weighted cohort.
**
Multivariable Cox regression adjusted for all characteristics in the study of weighted cohort.