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. Author manuscript; available in PMC: 2020 Aug 25.
Published in final edited form as: J Biophotonics. 2019 Dec 23;13(3):e201960091. doi: 10.1002/jbio.201960091

FIGURE 6.

FIGURE 6

Longitudinal tracking of tumor progression with ultrahigh-resolution optical coherence angiography (μODT)/ultrahigh-resolution optical coherence angiography (μOCA) and fluoresence imaging in vivo. A-D, μODT images of microcirculatory blood flow acquired on day 7, 14, 8 and 24 after tumor cell injection. Dashed green circles point to high capillary flow within the tumor. E-H and I-L, the corresponding μOCA and GFP fluoresence images. Dashed red circles point to either injection spot or dense neoagniogenic vasculature. M, time-course plots of capillary flow (red), capillary density (fill factor; yellow) and tumor proliferation (GFP fluorescence; green)