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. 2019 Mar 8;3:PO.18.00213. doi: 10.1200/PO.18.00213

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© 2019 by American Society of Clinical Oncology

Licensed under the Creative Commons Attribution 4.0 License: https://creativecommons.org/licenses/by/4.0/

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FIG 4. — (A-D) Kaplan-Meier plots for overall survival by (A) total number of alterations (actionable and nonactionable) detected, (B) whether the patient had a tumor with an alteration in an actionable gene, (C) type of therapy and absence of alterations in actionable genes, and (D) whether the patient had a tumor with an alteration in an actionable gene on the 409-genes next-generation sequencing panel received matched treatment. Only treatment with matched targeted therapy (C and D) was associated with significantly improved survival (P = .017 compared with patients treated with nonmatched therapy). HR, hazard ratio.