FIG 1.

Landscape of somatic mutations in endometrial cancers (ECs) in patients with pathogenic BRCA1/2 germline mutations. Nonsynonymous somatic mutations identified in 410 cancer-related cancer genes in ECs from germline BRCA1 (n = 8) and germline BRCA2 (n = 5) mutation carriers (left) are shown. The mutation types are color coded according to the legend. Selected amplifications and homozygous deletions are shown at the bottom of the figure. Information on the germline mutation status, somatic loss of heterozygosity of BRCA1/2, histologic type, microsatellite instability (MSI) status, and sequencing type is provided in the phenobar below the sample names. indel, insertions and deletions; MSK-IMPACT, Memorial Sloan Kettering–Integrated Mutation Profiling of Actionable Cancer Targets; NOS, not otherwise specified; SNV, single nucleotide variant; TCGA, The Cancer Genome Atlas; WES, whole-exome sequencing.