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Overview of statistical methods to model chemotherapy benefit as a function of EPclin score. (A) Risk of 10-year distant metastasis without chemotherapy. (B) Model risk of 10-year distance recurrence with chemotherapy. (C) Calculate absolute benefit from chemotherapy. ABCSG, Austrian Breast and Colorectal Cancer Study Group; EBCTCG, Early Breast Cancer Trialists’ Collaborative Group; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2.
