FIG 2.

Cumulative brain metastases incidence and death. (A) The cumulative incidence function of the probability of developing brain metastasis in the 83 patients with MET exon 14–altered metastatic lung cancers is shown. The probabilities at 12, 24, and 36 months are 24%, 35%, and 38%, respectively. (B) Hazard functions of patients with MET exon 14–altered metastatic lung cancers who do and do not have brain metastases are depicted. The lines represent the likelihood a patient will experience death as a function of time depending on the presence of brain metastasis at baseline. The risk ratio (RR) comparing the 2 groups at a specific time is calculated by the division of hazard rates at that time point. Compared with not having brain metastasis, having brain metastasis at 6, 12, and 24 months increases the risk of death by 2.61-, 2.73-, and 2.94-fold, respectively.