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. 2018 May 17;2:PO.17.00279. doi: 10.1200/PO.17.00279

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© 2018 by American Society of Clinical Oncology

Licensed under the Creative Commons Attribution 4.0 License: http://creativecommons.org/licenses/by/4.0/

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Fig 1. — Comparison between the genetic profile of the primary tumor, cell-free DNA (cfDNA), two circulating tumor cells (CTCs), and a single peripheral blood mononuclear cell (PBMC) in a patient with metastatic uveal melanoma. (A) Whole-body fluorodeoxyglucose–positron emission tomography scan of a patient with uveal melanoma at the time of blood collection. (B) Brightfield and florescent images of the two CTCs used for somatic chromosomal copy number alteration analysis. Cells were stained with a combination of antibodies against the melanoma markers melanoma antigen recognised by T cells 1 (MART1)/glycoprotein 100(gp100)/S100 calcium-binding protein β (S100β; green), CD45 (red), and 4',6-diamidino-2-phenylindole (DAPI; blue), taken at ×200 magnification. (C) Whole-genome sequencing somatic chromosomal copy number alteration profile of primary formalin-fixed paraffin-embedded tumor, cfDNA, two CTCs, and a single PBMC. The obtained sequence depth is indicated for each plot. Red and blue bars represent chromosomal losses or gains, respectively.