FIG 1.

(A) Frequencies of PAM50 subtypes in primary breast cancer and subsequent lung metastasis. For luminal A (LumA) breast cancers, the change in PAM50 subtype is significant (P = .02, Fisher’s exact test). (B) Alluvial plot showing molecular subtype conversion and number of cases with and without conversion (without normal-like [Normal] subtype). The majority of cases with subtype switching affected the LumA category. LumB, luminal B; HER2, human epidermal growth factor receptor 2 (HER2)–enriched; Basal, basal-like; n.s., not significant.