Table 3.

Percentage change in signal unit ratios at various time points after intrathecal gadobutrol in REF and iNPH patients.

Anatomical region			Time after i.th. gadobutrol													Overall significance
		Enhancement phase								Clearance phase
[FreeSurfer]	Group	1.5–2 h	P	2–4 h	P	4–6 h	P	6–9 h	P	24 h	P	48 h	4 weeks	P
Choroid plexus [31, 63]	REF	−3 ± 8	ns	22 ± 65	ns	57 ± 107	0.055	56 ± 118	0.019	24 ± 34	0.004	39	−8 ± 15	ns	<0.001
	iNPH	7 ± 25		21 ± 26		162 ± 127		191 ± 121		185 ± 112		108 ± 141	0 ± 18		<0.001
CSF, lateral ventricle [4, 43]	REF	−10 ± 8	ns	342 ± 957	ns	641 ± 1415	0.023	656 ± 1438	0.002	173 ± 325	0.001	228	−10 ± 12	ns	0.052
	iNPH	11 ± 28		296 ± 350		2598 ± 2179		3041 ± 1808		2272 ± 1217		869 ± 1104	−7 ± 19		<0.001

Note: Continuous variables given as mean ± standard deviation. P: Statistically significant differences determined by a linear mixed model for repeated measurements with time interval as fixed effect and a random intercept for patient. Numbers in brackets refer to FreeSurfer regions.

iNPH: idiopathic normal pressure hydrocephalus; REF: reference patients.