(a) Individual (N = 13) centrum semiovale (CS) volume of distribution, VT, at baseline from images reconstructed with 2, 3, and 4 OS-EM iterations of 30 subsets. Results from post-hoc testing with Dunn’s multiple comparison test are shown as p values. (b) Individual (N = 28) CS VT under blocking conditions from images reconstructed with 2, 3, and 4 OS-EM iterations. (c) Average baseline (filled circles) and blocking (open circles) CS VT at 2 OS-EM iterations. (d) Average baseline (filled circles) and blocking (open circles) CS VT at 4 OS-EM iterations. For (c) and (d), results from Mann-Whitney U test are shown as p values.