Table 3.

Hazard ratios for mortality according to hydroxychloroquine use in different subgroups.

	Hydroxychloroquine NO (N=817)	Hydroxychloroquine YES (N=2,634)
Subgroups	No. death/patient at risk	No. death/patient at risk	HR (95% CI)*
Women	80/361	116/940	0.63 (0.46 to 0.86)
Men	110/456	270/1,694	0.74 (0.60 to 0.93)
Age <70 years	22/357	93/1,542	0.76 (0.50 to 1.16)
Age ≥70 years	168/460	293/1,092	0.68 (0.56 to 0.83)
Highest degree of COVID-19 severity experienced at hospital
Mild pneumonia or less	28/424	40/1,358	0.70 (0.41 to 1.18)
Severe pneumonia	80/253	172/764	0.76 (0.58 to 0.99)
Acute respiratory distress syndrome	82/140	174/512	0.68 (0.52 to 0.90)
Use of other COVID-19 treatments^
No	101/439	64/570	0.63 (0.45 to 0.88)
Yes	89/378	322/2,064	0.77 (0.61 to 0.99)
C-Reactive Protein at basal**
<10 mg/L	56/412	125/1,138	1.23 (0.86 to 1.77)
≥10 mg/L	123/361	241/1,362	0.59 (0.47 to 0.73)

Abbreviations: HR, hazard ratios; CI, confidence intervals; *Propensity score analysis, inverse probability weighting, including hospital clustering as random effect covariate; multiple imputed analysis.

^Lopinavir/ritonavir or darunavir/cobicistat or tocilizumab or sarilumab or remdesivir or corticosteroids.

**Missing data for N=178. Frequencies and hazard ratios are based on a case complete analysis (N=3,273) without missing data for C-reactive Protein; multiple imputed analysis (N=3,451) yielded very similar results.