Table 1.

5-ALA fluorescence guided surgery.

Study	Year	Study type	No. of patients	Tumor type	Fluorescence	Postoperative outcomes	Comments
Eljamel et al.[41]	2009	prospective, single center	N = 30	14 NFA, 12 secreting PA (2 GH, 3 ACTH, 2 prolactin, 5 gonadotrophins) and 4 pituitary cysts.	Photodiagnostic system: 80.8% sensitivity and 75% specificity. Optical biopsy system: 95.5% sensitivity and 100% specificity	3 macroadenomas recurrences	PpIX-induced fluorescence detection helpful in locating 6 microadenomas when MRI scan were normal and macroadenomas do uptake and retain the photosensitizer
Marbacher et al. [36]	2014	prospective, single center	N = 458	12 PA	8.33% (1/12) positive fluorescence	n/a