Table 3.
Effect of ethanolic leaf extract of Annona squamosa Linn. on urinary volume, urinary pH, and body weight in ethylene glycol-induced urolithiatic rats
| Groups | Urinary volume (ml/24 h) | Urinary pH | Body weight (g) | |
|---|---|---|---|---|
| Initial | Final | |||
| Normal control | 8.03±0.33 | 7.1±0.129 | 150.32±1.45 | 164.66±1.11 |
| Negative control (EG) | 4.625±0.202a | 5.75±0.076a | 157.58±0.76 | 150.16±1.13a |
| Positive control (Cystone 750 mg/kg) | 8.31±0.139b | 7.5±0.09b | 161.62±1.2 | 168.16±0.87b |
| Test I (EEAS 250 mg/kg) | 6.58±0.060b | 6.75±0.66b | 169.54±1.14 | 172.83±0.477b |
| Test II (EEAS 500 mg/kg) | 7.98±0.094b | 7.43±0.143b | 169.21±3.3 | 176.12±0.47b |
Values are mean±SEM; n=6 in each group; aP<0.01 when compared to normal control; bP<0.01 when compared to urolithiatic control (one-way ANOVA followed by Dunnett’s test). EG=Ethylene glycol, ANOVA=Analysis of variance, SEM=Standard error of mean, EEAS= Ethanolic extract of annona squamosa