Table 4.

Association of genetic variants and antecedent conditions with EF in GERA non-Hispanic whites

	Univariate Models‡		BAG3 Multivariable Model§		TMEM40 Multivariable Model‖
Risk Factor/condition	β (SE)	P	β (SE)	P	β (SE)	P
BAG3 rs17617337	−0.82 (0.13)	6.73x10−10	−0.78 (0.13)	1.53x10−9	-	-
TMEM40 rs11719526	0.45 (0.12)	1.10x10−4	-	-	0.45 (0.11)	5.96x10−5
HF/cardiomyopathy	−8.70 (0.33)	3.88x10−150	-	-	-	-
Hypertension	−1.36 (0.22)	5.40x10−10	-	-	-	-
MI	−6.43 (0.32)	2.25x10−84	-	-	-	-
Atrial fibrillation	−3.04 (0.26)	1.45x10−30	-	-	-	-
Valvular disease	−3.24 (0.29)	2.57x10−28
Revascularization procedures	−3.78 (0.28)	2.22x10−40	-	-	-	-
*Any condition	−1.51(0.22)	1.78x10−11	-	-	-	-
Multiple conditions	−4.07(0.24)	2.88x10−65	-	-	-	-
None of the above conditions	1.51(0.22)	1.78x10−11	-	-	-	-
†Total number of conditions	−2.03(0.063)	4.21x10−222	−2.03(0.063)	9.76x10−222	−2.03(0.063)	2.51x10−222

Each analysis was adjusted for age at specimen collection, age at 1^st EF measurement, sex, data sources, and genetic ancestry PCs.

^*‘Any condition’ collapses all cardiac conditions (i.e. HF/cardiomyopathy, hypertension, MI, atrial fibrillation, valvular disease, and revascularization procedures).

^†‘Total number of conditions’ is a variable which accounts for the number of conditions a patient had (i.e., 0 to 6 for the following conditions: heart failure/cardiomyopathy, hypertension, myocardial infarction, atrial fibrillation, valvular disease, or revascularization procedures).

^‡The Univariate Model tests the association of each variable individually with EF;

^§Included BAG3 rs17617337 and total number of conditions;

^‖Included TMEM40 rs11719526 and total number of conditions.