Table 3.

Adverse Events

Adverse Events	CTCAE Grade					All Grade		Grade ≥3
	1	2	3	4	5	Total	%	Total	%
Pneumonitis	1	0	3	0	1	5	29.4	4	23.5
Dyspnea	2	0	4	0	0	6	35.3	4	23.5
Hypoalbuminemia	11	3	2	0	0	16	94.1	2	11.8
Lung infection	0	0	2	0	0	2	11.8	2	11.8
Hyponatremia	10	1	0	1	0	12	70.6	1	5.9
General fatigue	3	3	1	0	0	7	41.2	1	5.9
Anemia	6	6	0	0	0	12	70.6	0	0.0
AST increased	10	1	0	0	0	11	64.7	0	0.0
ALT increased	8	2	0	0	0	10	58.8	0	0.0
Cough	4	4	0	0	0	8	47.1	0	0.0
Appetite loss	5	2	0	0	0	7	41.2	0	0.0
Fever	4	2	0	0	0	6	35.3	0	0.0
Hyperglycemia	5	1	0	0	0	6	35.3	0	0.0
ALP increased	3	2	0	0	0	5	29.4	0	0.0
Creatinine increased	5	0	0	0	0	5	29.4	0	0.0
Serum amylase increased	5	0	0	0	0	5	29.4	0	0.0
Hypereosinophilia	4	0	0	0	0	4	23.5	0	0.0
CPK increased	2	1	0	0	0	3	17.6	0	0.0
Proteinuria	2	1	0	0	0	3	17.6	0	0.0
Hyperkalemia	3	0	0	0	0	3	17.6	0	0.0
Hypothyroidism	3	0	0	0	0	3	17.6	0	0.0
Nausea	3	0	0	0	0	3	17.6	0	0.0
Diarrhea	1	1	0	0	0	2	11.8	0	0.0
Thrombocytopenia	2	0	0	0	0	2	11.8	0	0.0
Blood bilirubin increased	2	0	0	0	0	2	11.8	0	0.0
Hypokalemia	2	0	0	0	0	2	11.8	0	0.0
Palpitations	2	0	0	0	0	2	11.8	0	0.0
Vomiting	2	0	0	0	0	2	11.8	0	0.0
Constipation	2	0	0	0	0	2	11.8	0	0.0
Abdominal pain	2	0	0	0	0	2	11.8	0	0.0
Pruritus	2	0	0	0	0	2	11.8	0	0.0
Peripheral sensory neuropathy	2	0	0	0	0	2	11.8	0	0.0
Radiation recall pneumonitisa	1	0	0	0	0	1	5.9	0	0.0

ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CPK, creatine phosphokinase; CTCAE, Common Terminology Criteria for Adverse Event.

^aIn the patient where the exclusion criteria were violated owing to a history of thoracic radiotherapy, an adverse event determined by the central judgment to be radiation recall pneumonitis with a CTCAE grade of 1 occurred. This was treated separately from pneumonitis in this report.