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. Author manuscript; available in PMC: 2021 Sep 15.
Published in final edited form as: Bioorg Med Chem. 2020 Jul 30;28(18):115661. doi: 10.1016/j.bmc.2020.115661

Scheme 1.

Scheme 1.

Highlighting key transformations from the total synthesis of caprazamycin A. Specifically, the A) installation of the syn-b-hydroxyamino acid, B) formation of the 1,4-diazepanone core, and C) introduction of the fatty acid side chain.