Plasma metanephrine results according to three levels of plasma normetanephrine in a general PPGL screening population (A), a supine endocrine testing population (B) and a cohort of confirmed PPGL (C). PMN, plasma metanephrine; PNM, plasma normetanephrine; PPGL, pheochromocytoma/paraganglioma, URL, upper reference limit of a (seated) reference range.