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. 2020 Aug 20;16(8):e1008733. doi: 10.1371/journal.ppat.1008733

Fig 6. 4X-SA-GP induced antibody responses are similar to those induced by the common adjuvant alum.

Fig 6

Wild-type female mice were immunized once a week for 3 weeks with PBS (n = 10), Empty-GPs (n = 10), 4X-SA-GP (n = 9) or the same amount of S. aureus antigens mixed with alum (n = 9). Serum was collected from each group 2 weeks after the third and final immunization. The serum was diluted 10X 3 times starting at 1:1000 and was then tested for total IgG antibodies specific for each of the 4 S. aureus proteins included in the vaccine by ELISA. The read-out of the assay is the optical density (OD) at 450 nm for each serum sample. Data are representative of three experiments and were analyzed using ANOVA and t test at each dilution. **p<0.01, ***p<0.001, ****p<0.0001; ns, not significant.