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. 2020 Jul 11;105(10):3203–3214. doi: 10.1210/clinem/dgaa443

Figure 1.

Figure 1.

Analysis plan for testing association to growth hormone response. The primary analysis was to combine patients in all 3 categories: growth hormone deficiency (GHD), small for gestational age (SGA) and idiopathic short stature (ISS), including all ancestries and performing a minimally adjusted analysis (age, sex, and principal components of genetic ancestry). Secondary analyses included testing GHD or ISS alone, limiting the analyses to individuals of European ancestry and adjusting for additional covariates. Additional covariates were gestational age in weeks, birthweight standard deviation score (SDS), age at GH start, average GH dose, height SDS (Prader) before treatment, average height of parents, and severity of GHD. For principal components of ancestry, the top 10 eigenvalues were used for all ancestry analyses and the top 3 eigenvalues for analyses of European ancestry samples. For single-variant analysis, associations were considered to have genome-wide significance if they reached P < 5 × 10–8 in the primary analysis; suggestive associations were those that reached P < 5 × 10–7 in the primary or secondary analyses.