Table 2.

Top Associations with GH response from Primary and Secondary GWAS Analyses

Chromosome (position)	SNP ID	MAF	Minor allele	GWAS Effect Size, Best Analysis	GWAS SE, Best Analysis	GWAS P value, Best Analysis	Ancestries/ Diagnosis/ Model for Best Analysis	Nearest Gene(s)	Replication Beta	Replication SE	Replication P Value	Meta- analysis Beta	Meta- analysis SE	Meta- analysis P Value
Associations from primary analysis with P < 5 × 10  –7
3 (118950499)	rs7628585	0.182	A	0.338	0.0621	5.54E-08	Primary analysis	B4GALT4	–0.091	0.181	6.17E-01	0.292	0.059	6.47E-07
1 (235531451)	rs1977748	0.411	T	–0.286	0.0563	3.75E-07	Primary analysis	TBCE	0.001	0.159	9.96E-01	–0.254	0.053	1.72E-06
Associations from secondary analyses with P < 5 × 10  –8
1 (10194439)	rs55704135	0.03	A	–0.934	0.159	4.24E-09	European/all/ maximum	UBE4B	–0.231	0.308	4.54E-01	–0.786	0.141	2.65E-08
3 (98383646)	rs189532746	0.013	A	–1.635	0.282	6.95E-09	All/ISS/ minimum	CPOX, ST3GAL6	NP	NP	NP	NP	NP	NP
12 (10300486)	rs78263566	0.025	G	1.685	0.283	8.50E-09	European/ GHD/ maximum	CLEC7A, OLR1	0.182	0.721	8.01E-01	1.485	0.2631	1.67E-08
8 (98853066)	rs74523128	0.01	A	2.516	0.430	1.52E-08	European/ GHD/ maximum	LAPTM4B	ND	ND	ND	ND	ND	ND
6 (116512418)	rs144751704	0.014	T	–1.299	0.232	2.12E-08	European/all/ minimum	NT5DC1/ COL10A1	NP	NP	NP	NP	NP	NP

Chromosome and position are based on the hg37 build of the human genome. Best analysis refers to the ancestry/diagnosis/model with the best P value in the GWAS for that variant. Replication and meta-analysis results are shown for that best analysis.

Abbreviations: GWAS, genome-wide association study; MAF, minor allele frequency; ND, not done; NP, not polymorphic; SNP, single nucleotide polymorphism.