Table 1. Baseline characteristics of the MVP NAFLD analytic cohort defined by the ALT-threshold definition.
| All Ancestries (n = 192,616) | European Ancestry (n = 148,354) | African Ancestry (n = 31,878) | Hispanic/Latino Ancestry (n = 12,384) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CHARACTERISTIC | TOTAL | CASES | CONTROLS | CASES | CONTROLS | CASES | CONTROLS | CASES | CONTROLS |
| Participants, n | 192,616 | 60,542 | 132,074 | 46,653 | 101,701 | 8,019 | 23,859 | 5,870 | 6,514 |
| Age at enrollment, mean ± sd | 64.5 ± 13.1 | 61.8 ± 12.1 | 66.2 ± 13.7 | 63.1 ± 11.9 | 64.2 ± 14.8 | 58.2 ± 10.9 | 57.0 ± 14.5 | 56.5 ± 13.2 | 59.9 ± 16.0 |
| Female, n (%) | 16,209 (8.4%) | 6,107 (10.1%) | 10,102 (7.6%) | 4,325 (9.3%) | 6,169 (6.1%) | 1,230 (15.3%) | 3,508 (14.7%) | 552 (9.4%) | 425 (6.5%) |
| BMI ≥30 kg/m2, n (%) | 88,547 (50.0%) | 34,676 (57.3%) | 53,871 (40.8%) | 26,509 (56.8%) | 39,672 (39%) | 47,75 (59.5%) | 11,115 (46.6%) | 3,392 (57.8%) | 3,084 (47.3%) |
| Hypertension, n (%) | 136,862 (71.1%) | 49,423 (81.6%) | 87,439 (66.2%) | 38,375 (82.3%) | 66,946 (65.8%) | 6,921 (86.3%) | 16,668 (69.9%) | 4,127 (70.3%) | 3,825 (58.7%) |
| Diabetes, n (%) | 49,961 (25.9%) | 21,161 (35%) | 28,800 (21.8%) | 16,215 (34.8%) | 21,232 (20.9%) | 2,907 (36.3%) | 5,899 (24.7%) | 2,039 (34.7%) | 1,669 (25.6%) |
| Prediabetes, n (%) | 72,505 (37.6%) | 20,210 (33.4%) | 52,295 (39.6%) | 15,664 (33.6%) | 40,043 (39.4%) | 2,571 (32.1%) | 9,790 (41%) | 2,075 (35.3%) | 2,462 (37.8%) |
| Dyslipidemia, n (%) | 97,698 (50.7%) | 40,967 (67.7%) | 5,6731 (43%) | 31,900 (68.4%) | 44,450 (43.7%) | 4,693 (58.5%) | 8,578 (26.9%) | 4,374 (74.5%) | 3,703 (56.8%) |
| Metabolic Risk Factor, n (%) | 179,822 (93.4%) | 58,964 (97.4%) | 120,858 (91.5%) | 45,487 (97.5%) | 93,870 (92.3%) | 7,835 (97.4%) | 21,282 (89.2%) | 5,675 (96.7%) | 5,706 (87.6%) |
| Alcohol misuse, n (%) | 59,304 (30.8%) | 18,571 (30.7%) | 40,733 (30.8%) | 14,659 (31.4%) | 32,966 (32.4%) | 2,142 (26.7%) | 5,909 (18.5%) | 1,770 (30.2%) | 1,858 (28.5%) |
| Peak ALT U/L, median [IQR] | 28 [21 – 42] | 43 [33 – 57] | 23 [18 – 29] | 44 [33 – 60] | 24 [19 – 31] | 42 [31 – 57] | 23 [18 – 31] | 47 [35 – 64] | 24 [19 – 31] |
| Cirrhosis and chronic liver disease not due to alcohol | 1616 (0.8%) | 1212 (2%) | 404 (0.3%) | 574 (1.2%) | 217 (0.2%) | 169 (2.1%) | 115 (0.5%) | 469 (8%) | 72 (1.1%) |
Abbreviations: ALT = alanine aminotransferase, AST = aspartate aminotransferase, BMI = body mass index, IQR = Interquartile range. All between and within-group comparisons were P<0.001.