Table 3. Previously published ALT-associated variants with genome-wide significance and association with maximal ALT at enrollment.
| NAFLD Phenotype: ALT-Max (n = 192,616) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 (Base) | Model 2 (Base + Alcohol) | Model 3 (Base+Alcohol+Metab) | ||||||||||||
| Gene | rsID | Chr | Pos | EA | EAF | Beta | SE | P | Beta | SE | P | Beta | SE | P |
| HSD17B13 | rs6834314 | 4 | 88213808 | A | 0.72 | 0.781 | 0.090 | 6.1E-18 | 0.759 | 0.091 | 7.7E-17 | 0.805 | 0.090 | 5.0E-19 |
| HSD17B13 | rs72613567 | 4 | 88231392 | T | 0.73 | 0.893 | 0.096 | 2.0E-20 | 0.867 | 0.097 | 4.6E-19 | 0.920 | 0.096 | 1.3E-21 |
| TRIB1 | rs2954021 | 8 | 126482077 | A | 0.50 | 0.787 | 0.080 | 6.4E-23 | 0.814 | 0.08 | 4.4E-24 | 0.762 | 0.080 | 1.4E-21 |
| ERLIN1 | rs10883437 | 10 | 101795361 | T | 0.61 | 0.501 | 0.081 | 5.3E-10 | 0.524 | 0.081 | 1.1E-10 | 0.534 | 0.081 | 3.4E-11 |
| ERLIN1 | rs11597390 | 10 | 101861435 | G | 0.64 | 0.789 | 0.085 | 1.5E-20 | 0.797 | 0.086 | 1.3E-20 | 0.801 | 0.085 | 3.8E-21 |
| ERLIN1 | rs11597086 | 10 | 101953705 | A | 0.58 | 1.114 | 0.087 | 9.3E-38 | 1.115 | 0.087 | 2.9E-37 | 1.140 | 0.087 | 1.9E-39 |
| ERLIN1 | rs11591741 | 10 | 101976501 | G | 0.58 | 1.090 | 0.086 | 5.8E-37 | 1.096 | 0.086 | 8.2E-37 | 1.120 | 0.086 | 5.6E-39 |
| PNPLA3 | *rs738409 | 22 | 44324727 | G | 0.23 | 2.580 | 0.097 | 1.9E-155 | 2.574 | 0.098 | 1.4E-152 | 2.684 | 0.097 | 3.9E-168 |
| PNPLA3 | rs2281135 | 22 | 44332570 | A | 0.17 | 2.263 | 0.105 | 4.4E-102 | 2.240 | 0.106 | 7.5E-99 | 2.357 | 0.105 | 9.5E-111 |
| PNPLA3 | rs2143571 | 22 | 44391686 | A | 0.18 | 1.235 | 0.098 | 1.0E-36 | 1.212 | 0.098 | 4.8E-35 | 1.276 | 0.097 | 3.7E-39 |
Abbreviations: rsID: dbSNP identifier (build 151), Chr: chromosome, Pos: base pair position on human genome reference hg19, EA: effect allele, EAF: effect allele frequency among Europeans (Million Veteran Program), Beta: effect size estimated increase in trait per increase copy of the effect allele (additive model). SE: Standard error on Beta, HSD17B13: Hydroxysteroid 17-Beta Dehydrogenase 13, TRIB1:Tribbles Homolog 1, ERLIN1: ER Lipid Raft Associated 1, PNPLA3: patatin-like phospholipase domain-containing protein 3. Model 1: adjusted for age, gender, and 10 principal components (PCs), Model 2: covariates in Model 1 + alcohol consumption at enrollment measured by the Alcohol Use Disorder Identification Test (AUDIT-C), Model 3: covariates in Model 2 + Type II diabetes/prediabetes, hypertension, dyslipidemia and BMI ≥ 30 kg/m2. P-values below 0.006 (adjusted for multiple comparisons) are shown in bold font.