Table 3. The effect of clinicopathological factors on recurrence and non-adjusted and adjusted hazard ratio among OSCC patients.

Cox proportional-hazards regression analysis of recurrence
			Recurrence		Univariate analysis (crude)			Multiple analysis (adjusted)
		Total	N	%	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI			P-value
Stage	1	988	160	16.1	1.000
	2	460	88	19.1	1.235	0.952–1.603	0.111
	3	215	35	16.2	1.085	0.752–1.564	0.663
	4	824	220	26.7	1.954	1.593–2.396	<0.001
T stage	1	1110	188	16.9	1.000	0.158–2.566	0.526
	2	600	126	21.0	1.322	0.208–3.405	0.810
	3	151	28	18.5	1.301	0.198–3.481	0.798
	4	668	170	25.4	1.749	0.276–4.489	0.880
N stage	0	1416	209	14.8	1.000
	1	182	46	25.3	1.851	1.345–2.547	<0.001	1.523	1.019	-	2.276	0.040
	2	309	111	35.9	3.174	2.520–3.999	<0.001	2.426	1.629	-	3.613	<0.001
	3	30	10	33.3	5.259	2.777–9.962	<0.001	3.140	0.939	-	10.500	0.063
Extranodal spread	No	1669	266	15.9	1.000			1.000
	Yes	268	102	38.0	3.156	2.509–3.970	<0.001	1.666	1.129	-	2.458	0.010
Close margin	No	2455	491	20.0	1.000
	Yes	80	23	28.8	1.527	1.005–2.320	0.047
Grade	Well	435	60	13.8	1.000			1.000
	Moderately	1964	405	20.6	1.672	1.275–2.194	<0.001	1.167	0.793	-	1.715	0.433
	Poor	136	42	30.9	3.029	2.041–4.495	<0.001	1.973	1.167	-	3.336	0.011

Following period was from time at OSCC diagnosed to June 30, 2019.