Table 1.

Study Design for Review of Cystic Endometrial Hyperplasia (CEH) in Longitudinal and Transverse Sections of Uterus in Female Harlan Sprague Dawley (Hsd:SD) Rats Previously Diagnosed with or without CEH

			Original Diagnosis: CEH			Original Diagnosis: No CEH
Study	Generation	PPM1	Animal Number	CEH Grade	Age (Days)2	Treated and Control Females for Comparison
						Control Animal Number3	Age (Days)	Treated Animal Number3	Age (Days)
A	F0	0	22	Mild	275	46	276
		0	36	Mild	276	8	275
		5000	150	Minimal	275	40	276	142	275
		5000	160	Mild	276	2	275	184	276
		5000	162	Mild	276	26	275	158	275
		5000	172	Minimal	276	30	276	176	276
	F1cP4	0	1100	Minimal	256	1112	250
		0	1102	Minimal	248	1082	250
		0	1168	Minimal	247	1042	251
		0	1178	Minimal	246	1096	248
		0	1180	Minimal	250	1056	252
		0	1198	Mild	241	1154	254
	F1cNP5	0	1008	Minimal	91	1006	91
		0	1038	Minimal	91	1158	93
		0	1064	Mild	91	1048	91
		0	1146	Minimal	91	1050	91
B	F1	0	1084	Minimal	127	1060	128
		0	1158	Minimal	132	1092	128

¹PPM = parts per million

²Age of animal at termination

³Treated and control animals chosen from same treatment group and generation for comparison purposes

⁴F1cP = F1c Parental Females

⁵F1cNP = F1c Nonparental Females