Table 2.

Study Design for Review of Cystic Endometrial Hyperplasia (CEH) in Longitudinal and Transverse Sections of Uterus in Female Harlan Sprague Dawley (Hsd:SD) Rats Previously Diagnosed with or without Endometrial Cyst

			Original Diagnosis: Cyst			Original Diagnosis: No Cyst or CEH
Study	Generation	PPM1	Animal Number	CEH Grade	Age (Days)2	Females for Comparison
						Control Animal Number3	Age (Days)	Treated Animal Number3	Age (Days)
A	F0	2500	98	Not Diagnosed	275	32	276	108	275
		5000	156	Not Diagnosed	275	38	276	144	275
	F1cP3	750	1358	Not Diagnosed	250	1090	245	1526	250
		750	1514	Not Diagnosed	248	1156	250	1396	254
		2500	1602	Not Diagnosed	255	1022	254	1604	254
		2500	1634	Not Diagnosed	250	1132	248	1644	250
		2500	1718	Not Diagnosed	251	1130	250	1664	255
	F1cNP4	0	1138	Not Diagnosed	91	1136	91
		0	1172	Not Diagnosed	93	1026	91
		0	1194	Not Diagnosed	91	1028	91
		2500	1628	Not Diagnosed	91	1020	91	1608	91
C	F1-Fert	0	1026	Not Diagnosed	131	1090	130
		0	1074	Not Diagnosed	129	1084	126
		0	1170	Not Diagnosed	133	1076	125
	F1-Fert	1000	1478	Not Diagnosed	127	1014	133
		6000	1942	Not Diagnosed	129	1056	128	2036	124
	F1-Tox	0	1080	Not Diagnosed	83	1094	83

¹PPM = parts per million

²Age of animal at termination

³Treated and control animals chosen from same treatment group and generation for comparison purposes

⁴F1cP = F1c Parental Females

⁵F1cNP = F1c Nonparental Females