Table 4.

Microscopic Evaluation for Cystic Endometrial Hyperplasia (CEH) in Longitudinal and Transverse Sections of Uterus in Harlan Sprague Dawley (Hsd:SD) Rats Previously Diagnosed with or without CEH

Study	Gen1	PPM2	Animal	Age (Days)3	Estrous Stage	Diagnosis: CEH
						Original	New
							Longitudinal	Transverse
A	F0	0	22	275	Persistent Estrus	Mild	Moderate	Moderate
		0	36	276	Persistent Estrus	Mild	Moderate	Moderate
		0	46	276	Diestrus	-4	-	-
		0	8	275	Late Proestrus	-	-	-
		0	40	276	Proestrus	-	-	-
		0	2	275	Late Estrus	-	-	-
		0	26	275	Metestrus	-	-	-
		0	30	276	Early Diestrus	-	Minimal	Minimal
	F1cP3	0	1100	256	Late Estrus	Minimal	Mild	Minimal
		0	1102	248	Metestrus	Minimal	-	-
		0	1168	247	Early Estrus	Minimal	Minimal	Minimal
		0	1178	246	Early Estrus	Minimal	Minimal	Minimal
		0	1180	250	Proestrus	Minimal	Minimal	-
		0	1198	241	Metestrus	Mild	Mild	Mild
		0	1112	250	Late Metestrus	-	-	-
		0	1082	250	Metestrus	-	-	-
		0	1042	251	Early Metestrus	-	-	-
		0	1096	248	Early Estrus	-	-	-
		0	1056	252	Late Metestrus	-	Minimal	Minimal
		0	1154	254	Diestrus	-	-	-
	F1cNP4	0	1008	91	Late Metestrus	Minimal	Minimal	Minimal
		0	1038	91	Metestrus	Minimal	Minimal	Minimal
		0	1064	91	Late Estrus	Mild	Mild	Mild
		0	1146	91	Metestrus	Minimal	Minimal	Minimal
		0	1006	91	Late Proestrus	-	-	-
		0	1158	93	Proestrus	-	-	-
		0	1050	91	Late Metestrus	-	-	-
B	F1	0	1084	127	Diestrus	Minimal	Minimal	Minimal
		0	1158	132	Repetitive Pseudopregnancy	Minimal	-	-
		0	1060	128	Early Estrus	-	-	-
		0	1092	128	Diestrus	-	-	-

¹Gen = Generation

²PPM = Parts per million

³Age of animal at termination

⁴”-“ = Not diagnosed