. Author manuscript; available in PMC: 2020 Aug 25.

Published in final edited form as: Toxicol Pathol. 2020 Jun 16;48(5):616–632. doi: 10.1177/0192623320931768

Table 5.

Microscopic Evaluation for Cystic Endometrial Hyperplasia (CEH) in Longitudinal and Transverse Sections of Uterus in Harlan Sprague Dawley (Hsd:SD) Rats Previously Diagnosed with or without Endometrial Cyst

Study	Gen¹	PPM²	Animal	Age (Days)³	Estrous Stage	Diagnosis: CEH
						Original	New
						Original	Longitudinal	Transverse
A	F0	2500	98	275	Early Estrus	-⁴	-	-
		0	32	276	Early Proestrus	-	Minimal	Minimal
		0	38	276	Late Metestrus	-	-	-
		2500	108	275	Metestrus	-	Minimal	-
	F1cP²	750	1514	248	Metestrus	-	Minimal	Minimal
		2500	1602	255	Late Proestrus	-	-	-
		2500	1634	250	Estrus	-	-	-
		2500	1718	251	Late Metestrus	-	-	-
		0	1090	245	Proestrus	-	-	-
		0	1156	250	Diestrus	-	-	-
		0	1022	254	Early Diestrus	-	Minimal	-
		0	1132	248	Early Metestrus	-	Mild	Mild
		0	1130	250	Late Proestrus	-	-	-
		750	1526	250	Late Metestrus	-	-	-
	F1cP²	750	1396	254	Early Estrus	-	Mild	Minimal
		2500	1604	254	Early Proestrus	-	-	-
		2500	1664	255	Early Proestrus	-	Minimal	Minimal
	F1cNP³	0	1138	91	Late Proestrus	-	-	-
		0	1172	93	Estrus	-	Minimal	-
		0	1194	91	Early Diestrus	-	-	-
		2500	1608	91	Estrus	-	-	-
		0	1136	91	Early Proestrus	-	-	-
		0	1026	91	Late Metestrus	-	-	-
		0	1020	91	Early Proestrus	-	Minimal	Minimal
C	F1	0	1026	131	Repetitive Pseudopregnancy	-	-	-
		0	1074	129	Diestrus	-	-	-
		0	1170	133	Late Diestrus	-	-	-
		1000	1478	127	Diestrus	-	-	-
		6000	1942	129	Late Proestrus	-	-	-
		0	1080	83	Early Proestrus	-	-	-
		0	1090	130	Diestrus	-	-	-
		0	1084	126	Repetitive Pseudopregnancy	-	-	-
		0	1076	125	Repetitive Pseudopregnancy	-	-	-
		1000	1014	133	Metestrus	-	-	-
		6000	1056	128	Late Metestrus	-	-	-
		0	1094	83	Proestrus	-	Minimal	Minimal
		6000	2036	124	Diestrus	-	-	-

Gen = Generation

PPM = Parts per million

Age of animal at termination

⁴

”-“ = Not diagnosed