Table 2.
Analysis of Eight SNPs in Severe cCSC
| SNP (Locus) | Alleles in Controls (Major/Minor) | Severe cCSC (n) | MAF in Severe cCSC | Controls (n) | MAF Among Controls | Unadjusted Allelic P | Allelic OR (95% CI) |
| rs10490924 (ARMS2) | G/T | 171 | 0.187 | 812 | 0.217 | 0.214 | 0.83 (0.62–1.11) |
| rs2070951 (NR3C2) | C/G | 172 | 0.494 | 1,385 | 0.468 | 0.350 | 1.11 (0.89–1.39) |
| rs800292 (CFH) | G/A | 172 | 0.372 | 798 | 0.235 | 0.0014* | 1.93 (1.51–2.47) |
| rs1061170 (CFH) | T/C | 172 | 0.282 | 803 | 0.353 | 0.012 | 0.72 (0.56–0.93) |
| rs1065489 (CFH) | G/T | 172 | 0.096 | 794 | 0.177 | 2.22 × 10−4* | 0.49 (0.34–0.72) |
| rs1329428 (CFH) | C/T | 171 | 0.588 | 787 | 0.429 | 0.0010* | 1.89 (1.49–2.40) |
| rs2284664 (CFH) | C/T | 171 | 0.316 | 805 | 0.219 | 1.21 × 10−4* | 1.65 (1.28–2.13) |
| rs3753394 (CFH) | C/T | 171 | 0.202 | 800 | 0.293 | 6.10 × 10−4* | 0.61 (0.46–0.81) |
*
Two-sided P values < 0.00556 were considered significant after correction for multiple testing.
ARMS2, age-related maculopathy susceptibility 2; CFH, complement factor H; MAF, minor allele frequency; NR3C2, nuclear receptor subfamily 3 Group C member 2.