Table 3.

Comparison of Allele Frequencies in Severe cCSC Versus Nonsevere cCSC and aCSC

SNPs (Locus)	Group 1*		Group 2†		Group 3‡		Group 2 Versus 1		Group 3 Versus 1
	Severe cCSC (n)	MAF	Non-severe cCSC (n)	MAF	aCSC (n)	MAF	Unadjusted Allelic P	Allelic OR (95% CI)	Unadjusted Allelic P	Allelic OR (95% CI)
rs10490924 (ARMS2)	171	0.187	243	0.193	132	0.174	0.821	0.96 (0.67–1.37)	0.683	1.09 (0.72–1.66)
rs2070951 (NR3C2)	172	0.494	269	0.520	132	0.538	0.447	0.90 (0.69–1.18)	0.216	0.82 (0.59–1.13)
rs800292 (CFH)	172	0.372	245	0.296	133	0.320	0.021	1.41 (1.05–1.89)	0.177	1.26 (0.90–1.77)
rs1061170 (CFH)	172	0.282	245	0.320	133	0.259	0.235	0.83 (0.62–1.13)	0.534	1.12 (0.78–1.61)
rs1065489 (CFH)	172	0.096	244	0.133	134	0.119	0.101	0.69 (0.44–1.08)	0.350	0.78 (0.47–1.31)
rs1329428 (CFH)	171	0.588	244	0.510	133	0.579	0.0275	1.37 (1.04–1.81)	0.828	1.04 (0.75–1.43)
rs2284664 (CFH)	171	0.316	244	0.275	134	0.287	0.199	1.22 (0.90–1.65)	0.448	1.14 (0.81–1.62)
rs3753394 (CFH)	171	0.202	242	0.273	131	0.263	0.0192	0.67 (0.48–0.94)	0.073	0.71 (0.48–1.0)

Two-sided P values < 0.00556 were considered significant after correction for multiple testing.

^*Group 1: severe cCSC.

^†Group 2: nonsevere cCSC.

^‡Group 3: aCSC.

ARMS2, age-related maculopathy susceptibility 2; CFH, complement factor H; MAF, minor allele frequency; NR3C2, nuclear receptor subfamily 3 Group C member 2.