Table 2. Association between the median head circumference z-score at birth with the gestational trimester of maternal Zika virus infection and the severity of brain Computed Tomography (CT) lesions in children with Congenital Zika Syndrome.
| Variables | Head circumference z-score at birth | ||
|---|---|---|---|
|
| |||
| n (%) | Median (IQRf) | p value | |
| Gestational trimester of maternal ZIKV infection (n=74) a | 0.001g | ||
| 1st | 50 (67.6) | -3.22 (2.37) | |
| 2nd/3rd | 24 (32.4) | -1.83 (2.09) | |
| Severity of brain CT lesions (n=92) b | <0.001h | ||
| Mildc | 14 (15.2) | -1.62 (3.68) | |
| Moderated | 39 (42.4) | -2.00 (2.18) | |
| Severee | 39 (42.4) | -4.12 (2.03) | |
aTwenty-four cases whose mothers were asymptomatic, three mothers who were unable to report the presence of signs and symptoms suggestive of ZIKV infection and seven newborns that did not have their head circumference recorded at birth were excluded; bFifteen cases that did not have their head circumference recorded at birth and one that did not undergo brain computed tomography were excluded; cPresence of cerebral calcifications and/or slight reduction of the cerebral parenchyma with or without ex-vacuum ventriculomegaly; dPresence of malformation of the cortical development and/or posterior fossa (cerebellum or brain stem); eSevere reduction of cerebral parenchyma with ex-vacuum or hypertensive ventriculomegaly; fInterquartile range; gMann-Whitney test; hKruskal-Wallis test.