Table 3. Association between the severity of brain computed tomography (CT) lesions and diagnostic classification (highly and moderately probable) in children with Congenital Zika Syndrome.

Severity of brain CT lesions (n=66)	Diagnostic Classification
	Highly probabled n (%)	Moderately probablee n (%)	p value
Milda	7 (21.2)	7 (21.2)	0.947f
Moderateb	17 (51.5)	15 (45.5)
Severec	9 (27.3)	11 (33.3)

^aPresence of cerebral calcifications and/ or slight reduction of the cerebral parenchyma with or without ex-vacuum ventriculomegaly; ^bPresence of malformation of the cortical development and/or posterior fossa; ^cSevere reduction of cerebral parenchyma with ex-vacuum or hypertensive ventriculomegaly; ^dBrain CT lesions suggestive of CZS and negative serology for the TORCHSinfections; three children have positive IgM; ^eBrain CT lesions suggestive of CZS, but without all serologies for the TORCHS infections performed or with inconclusive results; ^fFisher’s exact test.