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. 2020 Aug 25;533(3):467–473. doi: 10.1016/j.bbrc.2020.08.086

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Fig. 4 — Prediction of the putative binding site for andrographolide in 2019-nCoV M^pro and SARS-CoV M^pro. (A) Overall predicted surface model for the complex of 2019-nCoV M^pro (cyan) and andrographolide (green) was established. (B) Amplified region of catalytic pocket highlighting the hydrogen bonds (yellow dot line) between M^pro residues and andrographolide. (C) The distance (red dot line) between M^pro Cys¹⁴⁵ (yellow) and Michael acceptor carbon (magenta) of andrographolide is shown. (D) Overall predicted surface model for the complex of SARS-CoV M^pro (cyan) and andrographolide (green) was established. (E, F) Amplified regions of catalytic pocket for complex in (D). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)