Table 1.

When referral/discussion with the LTU is required for a patient with ALF⁷

Paracetamol induced acute liver failure	Non-paracetamol induced acute liver failure
Arterial pH <7.30 or HCO3 <18 INR >3.0 on day two or >4.0 thereafter Oliguria and/or AKI Altered level of consciousness Hypoglycaemia Elevated arterial lactate (>4 mmol/L) unresponsive to fluid resuscitation	pH <7.30 or HCO3 <18mmol/l INR >1.8 Oliguria/renal failure or Na <130 mmol/L Encephalopathy, hypoglycaemia or metabolic acidosis Bilirubin >300 umol/L (17.6 mg/dL)

AKI, acute kidney injury; ALF, acute liver failure; CLF, chronic liver failure; INR, international normalised ratio; LT, liver transplantation; LTU, liver transplant unit.