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. 2020 Aug 10;46(4):1477–1489. doi: 10.3892/ijmm.2020.4699

Figure 6.

Figure 6

Overexpression of LATS1 inhibits FOXD2-AS-induced cell proliferation, migration and invasion. (A and B) mRNA level of LATS1 in MCF-7 and MDA-MB-468 cells was detected by RT-qPCR in LATS1-overexpressing cells. ***P<0.001, vs. overexpression-NC (oe-NC). Following transfection with pcDNA-FOXD2-AS1, cells were transfected with pcDNA-LATS1 to overexpress LATS1. (C and D) CCK-8 assay was performed to determine the proliferation of the differently treated cells. (E) Migratory ability of MCF-7 cells in the different treatment groups was determined by wound healing assay. (F) Invasive ability of MCF-7 cells in the different treatment groups was determined by Transwell assay. (G) Migratory ability of MDA-MB-468 cells in the different treatment groups was determined by wound healing assay. (H) Invasive ability of MDA-MB-468 cells in the different treatment groups was determined by Transwell assay. ***P<0.001, vs. pcDNA-NC; ###P<0.001, vs. FOXD2-AS1 + shRNA-NC. LATS1, large tumor suppressor homolog 1.