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. 2020 Jul 15;46(4):1289–1300. doi: 10.3892/ijmm.2020.4675

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Copyright: © Wuxiao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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miR-145 targets MRP1 and ABCE1. (A) Binding sites between miR-145 and ABCE1, and between miR-145 and MRP1 predicted by bioinformatics software and website, and relative ABCE1 and MRP1 luciferase activity measured by dual-luciferase reporter gene assay. (B) Relative mRNA expression of ABCE1 and MRP1 detected by RT-qPCR. (C) Relative protein expression of ABCE1 detected by western blot analysis. ^**P<0.01; n=3. Data in (A and B) were analyzed by two-way ANOVA, and data in (C) were analyzed by one-way ANOVA. Tukey's multiple comparisons test was used as a post hoc test. ADM, adriamycin; miR-145, microRNA-145; MRP1, multidrug resistance protein 1; ABCE1, adenosine triphosphate (ATP)-binding cassette (ABC) transporter E1.