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. 2020 Jul 15;46(4):1289–1300. doi: 10.3892/ijmm.2020.4675

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Copyright: © Wuxiao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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ABCE1 activation reverses the promoting effects of miR-145 overexpression on K562/ADM cell sensitivity to ADM. (A) Relative protein expression of ABCE1 detected by western blot analysis. (B) Relative cell viability in each group detected by MTT assay. (C) Relative cell colonies in K562/ADM cells treated with 6 µmol/l ADM measured by colony formation assay. (D) Relative apoptosis of K562/ADM cells treated with 6 µmol/l ADM measured by flow cytometry. (E) Levels of MRP1 and P-gp of K562/ADM cells with 6 µmol/l ADM measured by western blot analysis. ^**P<0.01; n=3. Data in (A-D) were analyzed by one-way ANOVA, and data in (E) were analyzed by two-way ANOVA. Tukey's multiple comparisons test was used as a post hoc test. ADM, adriamycin; miR-145, microRNA-145; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; MRP1, multidrug resistance protein 1; P-gp, P-glycoprotein.