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. 2020 Jul 22;46(4):1514–1524. doi: 10.3892/ijmm.2020.4681

Figure 2.

Figure 2

miR-135b-5p agomir enhances the anti-proliferation effects of trastuzumab via inducing apoptosis. (A) Annexin V/PI staining in BT-474 cells was detected by flow cytometry. (B) Expression levels of Bax, cleaved caspase 3 and Bcl-2 in BT-474 cells were detected using western blotting. The relative expression levels of (C) Bax, (D) cleaved caspase-3 and (E) Bcl-2 were quantifiedby normalizing to β-actin levels. *P<0.05 and **P<0.01 vs. control; ##P<0.01 vs. trastuzumab. miR, microRNA; PI, propidium iodide.