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. 2020 Jul 22;46(4):1514–1524. doi: 10.3892/ijmm.2020.4681

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Anti-migration and anti-invasion effects of trastuzumab on breast cancer cells is enhanced by miR-135b-5p agomir. BT-474 and SK-BR-3 cells were transfected with 1 µg/ml trastuzumab, 50 nM miR-135b-5p agomir or a combination of trastuzumab and miR-135b-5p agomir for 24 h. Cell migration assay was performed to evaluate the migration ability of (A) BT-474 and (B) SK-BR-3 cells. Magnification ×200. Cell invasion assay was performed to evaluate the invasion ability of (C) BT-474 and (D) SK-BR-3 cells. Magnification, ×200. ^*P<0.05 and ^**P<0.01 vs. control; ^##P<0.01 vs. trastuzumab. miR, microRNA.