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. 2020 Aug 3;46(4):1321–1334. doi: 10.3892/ijmm.2020.4692

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Copyright: © Lyu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Signaling pathways related to the angiogenic function of NRP1 as determined using the STITCH website. (A) Pathway analysis of differentially expressed proteins detected using the human angiogenesis antibody array and DEGs from RNA-Seq. The maximum number of interactors for the 1st shell and 2nd shells were set as no more than 5 and the score of predicted functional partners was >0.999. (B) The top 20 proteins which were most closely related to NRP1. The maximum number of interactors for the 1st shell was no more than 20 interactors and the score of predicted functional partners was >0.935. The minimum required interaction score was a medium confidence of 0.400. NRP1, neuropilin 1; DEG, differentially expressed gene; GRB2, growth factor receptor-bound protein 2; EGFR, epidermal growth factor receptor; COPS6, COP9 constitutive photomorphogenic homolog subunit 6; SPRY2, sprout homolog 2; COPS4, COP9 constitutive photomorphogenic homolog subunit 4; VEGFA, vascular endothelial growth factor A; KDR, kinase insert domain receptor; FLT1, fms-related tyrosine kinase 1; SEMA3A, semaphorin 3A; PLXNA1, plexin A1, coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D; PLXNA2, plexin A2, coreceptor for SEMA3A and SEMA6A; PLXNA4, plexin A4, coreceptor for SEMA3A; SEMA3C, semaphorin 3C; PGF, placental growth factor; CHL1, close homolog of L1; SEMA3F, semaphorin 3F; phosphate, phosphoric acid; SEMA3D, semaphorin 3D; SEMA3E, semaphorin 3E; VEGFB, vascular endothelial growth factor B; PLXND1, plexin D1, cell surface receptor for SEMA4A and for class 3 semaphorins; GIPC1, GIPC PDZ domain-containing family, member 1; FGF2, fibroblast growth factor 2; DPYSL2, dihydropyrimidinase-like 2; FARP2, FERM, RhoGEF and pleckstrin domain protein 2.