Table 2.

AF in GnomAD genome (V3) database of the 2 variants of SERPINB11 and CYP2D6 reported by Rakela et al. in a cohort of adult patients with acute liver failure of indeterminate etiology

Population	SERPINB11: c.268G>T, p.Glu90Ter (rs4940595)				CYP2D6: c.1457G>C, p.Ser486Thr (rs1135840)
	Allele count	Allele number	Homozygotes	AF	Allele count	Allele number	Homozygotes	AF
African	21,033	41,932	5,329	0.502	26,148	40,822	8,881	0.641
Amish	604	900	199	0.671	466	884	128	0.527
Ashkenazi Jewish	2,171	3,322	723	0.654	2,138	3,312	714	0.646
East Asian	1,206	3,124	232	0.386	2,162	3,060	782	0.707
European (Finnish)	6,987	10,438	2,314	0.669	5,217	10,388	1,330	0.502
European (Non-Finnish)	46,721	64,532	16,858	0.724	35,748	64,030	10,432	0.558
Latino	8,124	13,646	2,430	0.595	6,615	13,548	1,734	0.488
South Asian	1,904	3,028	597	0.629	1,663	2,972	489	0.559
Other	1,362	2,150	438	0.633	1,223	2,126	369	0.575
Total	90,112	143,072	29,120	0.629	81,380	141,142	24,859	0.577

AF, allele frequency.