(
a) Left - local Manhattan plot for the
cis region of gene SMC2 (lead pQTL rs7872034), displaying eQTL and pQTL association negative log p-values, as well as negative log p-values obtained from a GWAS of invasive ovarian cancer (
Phelan et al., 2017) (pQTL cumulative co-localisation posterior probability 0.8; eCAVIAR). Right: scatter plot with eQTL and pQTL effect sizes (y-axis) juxtaposed with effect sizes on invasive ovarian cancer (x-axis). The red triangle indicates the lead pQTL for protein and mRNA effects. (
b) Local Manhattan plot of the
cis region for the gene TRIM5 (lead pQTL missense variant rs11601507) displaying eQTL and pQTL association negative log p-values, as well as negative log p-values obtained from a GWAS study for coronary artery disease risk (
van der Harst and Verweij, 2018). Right: scatter plot with eQTL and pQTL effect sizes juxtaposed with effect sizes on coronary artery disease risk. Left plot insert shows the position in
Q9C035, the protein encoded by TRIM5, of the missense variant rs11601507 and of the peptides used for protein quantification.