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HER2 signalling pathway inhibitor.
| Inhibitor (initial) | Rapamycin (R) | AZD2014 (A) | BEZ235 (B) | Erotinib (E) | Lapatinib (L) | MK2206 (M) | OSI-906 (O) |
|---|---|---|---|---|---|---|---|
| Target | mTOR | mTOR | PI3K/mTOR | EGFR | EGFR/HER2 | Akt1, Akt2, Akt3 | IGFR/IR |
| IC50a | 0.10nM | 335nM | 43.1nM | 551nM | 7.30nM | 250nM | 437nM |
| Concentration used | 10nM | 1 μM | 1μM | 1μM | 1μM | 1μM | 1μM |
IC50 values were obtained using inhibitors on SKBR3R cells.
