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. Author manuscript; available in PMC: 2020 Aug 25.
Published in final edited form as: Biomarkers. 2015;20(5):313–322. doi: 10.3109/1354750X.2015.1068865

Table 3.

Correlation between marker expression and cell viability post-HER2 pathway-targeted drug treatment in trastuzumab-resistant cell models.

Cell model Marker Correlation coefficienta p Value
pERK1/2  0.13  0.73
pAkt  0.17  0.67
BT474R p-rpS6  0.78  0.013
pS6K1  0.73  0.025
p-mTOR  0.60  0.088
pHER2  0.067  0.86
p4EBP1  0.20  0.61

pERK1/2   −0.05    0.9
pAkt  0.35  0.36
SKBR3R p-rpS6  0.88  0.002
pS6K1  0.64  0.061
p-mTOR  0.62  0.077
pHER2   <0.01  0.99
p4EBP1  0.72  0.030
a

Spearman correlation coefficient.