Table 3.
Inactivated vaccine schedule for inflammatory bowel disease patients
| Vaccine (brand names) | Target group | Dosing schedulea | Comments |
|---|---|---|---|
| Influenza (FluQuadri) | All patients | 0.5 mL IM annually | Live-attenuated intranasal influenza vaccine is contraindicated in immunosuppressed patients |
| Hepatitis A (Havarix, Biovac A) | All patients | 0.5 mL IM at 0 and 6 months | Titer testing before vaccination is recommended |
| Hepatitis B (Engerix-B, Cefvac-B, GeneVac-B, Shanvac-B) | All patients | 1 mL IM at 0,1 and 6 months | Antibody titer testing before vaccination is recommended. Double-dose vaccine, accelerated double-dose, or combined hepatitis A and B vaccine is also recommended |
| Human papilloma virus (Gardasil) |
9–14 years 15–26 years 27–45 years |
0.5 mL IM at 0 and 6 months 0.5 mL IM at 0, 2, and 6 months 0.5 mL IM at 0, 2, and 6 months |
Quadrivalent vaccine targeted against HPV types 6, 11, 16, and 18 is recommended Based on shared clinical decision between patient and care provider |
|
Tetanus diphtheria Pertussis–Tdap (Boostrix) |
All patients | 0.5 mL IM single dose between age 11–64 years | A tetanus diphtheria- Td vaccine booster every 10 years is recommended |
| Pneumococcus (Prevenar 13, Pneumovax 23) | All patients | 0.5 mL IM PCV13 followed by a dose of 0.5 mL IM PPSV23 after 2–12 months; another dose of PPSV23 should be administered 5 years after the initial PPSV23 dose and the third dose after age of 65 years | Patients may receive PCV13 1 year following PPSV23 if the later vaccine was given first |
|
Meningococcal Vaccine (Menactra) |
High-riskb patients between age 2–55 years | 0.5 mL IM two doses over 8–12 weeks apart | Due to interference with PCV 13 immune response, Menactra should be given at least after 1-month interval of PCV13 vaccine |
|
Herpes Zoster (Shingrix) |
Patient age > 50 years | 0.5 mL IM two doses at 0 and 2–6 months | Patients who previously received the live vaccine should complete the Shingrix series as recommended |
IM intramuscular, HPV human papillomavirus, Td Tetanus and diphtheria vaccine, PCV pneumococcal vaccines, PPSV pneumococcal polysaccharide vaccine, T dap tetanus, diphtheria, and acellular pertussis
aDose of vaccine may vary. Please refer to the product monograph before administration
bSee text