Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
In vitro cytotoxicity (GI50, μM) of compounds 24a and 29a on four human cell cancer lines.
| Compd. | Family | TRPM8 IC50 (μM) | Lung-NSCLC | Colon | Breast | Pancreas |
|---|---|---|---|---|---|---|
| A549 | HT29 | MDA-MB-231 | PSN1 | |||
| 24a | β-Lactam | 2.4 ± 1.2 | 3.29 | 4.16 | > 17.3 | 5.55 |
| 29a | β-Lactam | 0.4 ± 1.5 | 5.90 | 7.11 | 12.7 | 6.42 |
| 13ab | 2-KP | 17,9 ± 1.3 | > 17.8 | > 17.8 | > 17.8 | > 17.8 |
| 15ab | 2-KP | 1.8 ± 1.9 | > 17.8 | > 17.8 | > 17.8 | 6.4 |
| 30ab | 2-KP | 0.16 ± 1.6 | 12.7 | > 17.3 | > 17.3 | 8.3 |
| Doxorubicin.HCl | − | 0.24 | 0.19 | 0.17 | 0.17 |
